Basically....YES!!...it can make a big difference!
Most monomers and polymers are formulated to work together. To get the optimum results you should use the full system of any brand.
You can use the EzFlow Boogie Nights powders with any monomer and get great results....but I must admit I just always use them with the EzFlow Q monomer and that way I know I will get the best results.
What product system have you been trained in? and do you have any reason why you wouldn't want to use their monomer liquid?